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Journal Article 85

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acute myeloid leukemia 9

acute promyelocytic leukemia 7

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chronic hepatitis B 5

chronic kidney disease 4

Philadelphia chromosome 2

acute-on-chronic liver failure 2

biomarker 2

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The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia

Jessica Fredericks, Ruibao Ren

Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 452-461 doi: 10.1007/s11684-013-0304-0

Abstract:

BCR/ABL is the causative agent of chronic myelogenous leukemia (CML).Tyrosine177 of BCR is a Grb2 binding site required for BCR/ABL-induced CML in mice.NRAS (NRASG12D) to a vector containing a BCR/ABL^Y177F mutant “rescues” the CMLwell-characterized RAS effector loop mutants and determine that the RAL pathway is important for rapid induction of CMLfrom the present study support the notion of RAL inhibition as a potential therapy for BCR/ABL-induced CML

Keywords： BCR/ABL chronic myelogenous leukemia (CML) RAS RAL

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allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronicmyelogenous leukemia in the accelerated phase

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 304-311 doi: 10.1007/s11684-015-0400-4

Abstract:

In the tyrosine kinase inhibitor (TKI) era, imatinib is the first-line therapy for patients with chronicmyeloid leukemia (CML) in chronic or accelerated phase.This study retrospectively analyzed the efficacy of TKI₂ and HSCT for treatment of CMLNinety-three patients with CML registered in the Chinese CML alliance database from February 2001 toresults indicated that allo-HSCT may be superior to nilotinib and dasatinib for adult patients with CML

Keywords： chronic myeloid leukemia imatinib dasatinib nilotinib allogeneic hematopoietic stem cell transplantation

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Four-year follow-up of patients with imatinib-resistant or intolerant chronic myeloid leukemia receiving

Xiaojun Huang, Qian Jiang, Jianda Hu, Jianyong Li, Jie Jin, Fanyi Meng, Zhixiang Shen, Ting Liu, Depei Wu, Jianmin Wang, Jianxiang Wang

Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 344-353 doi: 10.1007/s11684-018-0639-7

Abstract: Dasatinib is a highly effective second-generation tyrosine kinase inhibitor used to treat chronic myeloidleukemia (CML).This report from the 4-year follow-up revealed that 73% of 59 patients in chronic phase (CML-CP) and32% of 25 patients in accelerated phase (CML-AP) remained under treatment.The initial dosage of dasatinib for CML-CP and CML-AP patients were 100 mg once daily and 70 mg twice

Keywords： chronic myeloid leukemia (CML) dasatinib tyrosine kinase inhibitor long-term follow-up

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Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 204-211 doi: 10.1007/s11684-012-0202-x

Abstract:

We evaluated the outcomes of chronic myeloid leukemia (CML) patients in three clinical phases, namely, chronic (CP), accelerated (AP), and blast (BP) phases, receiving imatinib treatment.The single-institution treatment experiences of Chinese patients with CML were presented.A total of 275 CML patients (CP, 210; AP, 24; and BP, 41) who received imatinib between February 2001

Keywords： imatinib chronic myeloid leukemia complete cytogenetic response

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Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidenticalhematopoietic stem cell transplantation in acute myeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 667-679 doi: 10.1007/s11684-019-0702-z

Abstract: Chronic graft-versus-host disease (cGVHD) is a major complication following unmanipulated haploidenticalfactors for cGVHD in patients who underwent anti-thymocyte globulin-based haplo-HSCT for acute myeloid leukemia

Keywords： acute graft-versus-host disease chronic graft-versus-host disease National Institutes of Health consensuscriteria acute myeloid leukemia anti-thymocyte globulin

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New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 129-134 doi: 10.1007/s11684-014-0339-x

Abstract:

Chronic hepatitis B virus (HBV) infection is a significant threat to public health and an enormousMechanisms responsible for chronic HBV infection remain poorly understood.A better understanding of the natural course of chronic HBV infection may shed new light on the mechanismsNatural course of chronic HBV infection is conventionally viewed as an uninterrupted process that isand reinfection, and such cycles prolong the chronic HBV infection course.

Keywords： hepatitis B virus chronic HBV infection natural course hepatitis B seroconversion

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Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 45-52 doi: 10.1007/s11684-011-0117-y

Abstract:

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia.directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemiacells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the diseasea potentially curable type of leukemia.

Keywords： acute promyelocytic leukemia arsenic all-trans retinoic acid survival

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: In patients with chronic renal failure, whether they have had hemodialysis or not, the specificity ofIt has been recently shown that some tumor markers are higher in patients with chronic kidney diseaseThe 232 non-dialysis patients with CKD and 37 chronic uremic patients treated with maintenance hemodialysis

Keywords： CKD non-dialysis valuable detection chronic

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Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking

Xuqiang Wei, Baoyan Liu

Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 767-775 doi: 10.1007/s11684-020-0785-6

Abstract: Most RCTs conclude that acupuncture procedures for chronic low back pain (CLBP) had no significant difference

Keywords： chronic low back pain sham acupuncture acupuncture methodology therapeutic evaluation

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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Acute myeloid leukemia (AML) is a very heterogeneous neoplasm of the hematopoietic stem cell.

Keywords： acute myeloid leukemia mutations risk stratification

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Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 17-23 doi: 10.1007/s11684-014-0313-7

Abstract:

Chronic hepatitis B is a major health burden worldwide.progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronicOn the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis

Keywords： chronic hepatitis B therapeutic antigen-antibody complexes DNA vaccine

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Perceived resource support for chronic illnesses among diabetics in north-western China

Huiqin Zhong,Ya Shao,Ling Fan,Tangshen Zhong,Lu Ren,Yan Wang

Frontiers of Medicine 2016, Volume 10, Issue 2, Pages 219-227 doi: 10.1007/s11684-016-0441-3

Abstract: study aims to analyze support from multiple and multilevel sources for diabetic patients by using the ChronicFactors affecting the utilization of chronic illness resources were determined through univariate analysis297 diabetic patients surveyed, 67% failed to reach the standard (more than 3 points) of utilizing chronicImproved utilization of chronic illness resources was conducive for proper diabetes self-management.Furthermore, the level of utilization of chronic illness resources increased with age, literacy level

Keywords： chronic illness resources survey diabetes community north-western China

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Hence, we aimed to explore its definite role in the development of acute myeloid leukemia (AML) and emphasize

Keywords： acute myeloid leukemia FGF13 prognosis immune-related genes bone marrow niches

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Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 271-276 doi: 10.1007/s11684-009-0054-1

Abstract: between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosis with chronicA total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followedProgression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up

Keywords： hepatitis B chronic viral load liver cirrhosis

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Advances in some common chronic liver diseases

Ke-Qin Hu

Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 127-128 doi: 10.1007/s11684-014-0341-3

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Title Author Date Type Operation

The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia

Jessica Fredericks, Ruibao Ren

Journal Article

allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronicmyelogenous leukemia in the accelerated phase

Lanping Xu,Huanling Zhu,Jianda Hu,Depei Wu,Hao Jiang,Qian Jiang,Xiaojun Huang

Journal Article

Four-year follow-up of patients with imatinib-resistant or intolerant chronic myeloid leukemia receiving

Xiaojun Huang, Qian Jiang, Jianda Hu, Jianyong Li, Jie Jin, Fanyi Meng, Zhixiang Shen, Ting Liu, Depei Wu, Jianmin Wang, Jianxiang Wang

Journal Article

Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Journal Article

Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidenticalhematopoietic stem cell transplantation in acute myeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Journal Article

New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Journal Article

Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

Acupuncture is ineffective for chronic low back pain? A critical analysis and rethinking

Xuqiang Wei, Baoyan Liu